of 52 results for "cytotec misoprostol" Misoprostol in Midtrimester Termination of Pregnancy: Oral and Vaginal Misoprostol in Midtrimester Termination of Pregnancy.

Drugs other than those listed here may also interact with misoprostol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products. Where can I get more information? Your pharmacist has more information about misoprostol written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.

Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Carcinogenesis, mutagenesis, impairment of fertility There was no evidence of an effect of Cytotec on tumor occurrence or incidence in rats receiving daily doses up to times the human dose for 24 months.

Similarly, there was no effect of Cytotec on tumor occurrence or incidence in mice receiving daily doses up to times the human dose for 21 months.

The mutagenic potential of Cytotec was tested in several in vitro assays, all of which were negative. Misoprostol, when administered to breeding male and female rats at doses 6. These findings suggest the possibility of a general adverse effect on fertility in males and females. Congenital anomalies sometimes associated with fetal death have been reported subsequent to the unsuccessful use of misoprostol as an abortifacient, but the drug's teratogenic mechanism has not been demonstrated.

Several reports in the literature associate the use of misoprostol during the first trimester of pregnancy with skull defects, cranial nerve palsies, facial malformations, and limb defects. Cytotec is not fetotoxic or teratogenic in rats and rabbits at doses and 63 times the human dose, respectively. Cytotec may endanger pregnancy may cause abortion and thereby cause harm to the fetus when administered to a pregnant woman. Cytotec may produce uterine contractions, uterine bleeding, and expulsion of the products of conception.

Abortions caused by Cytotec may be incomplete. If a woman is or becomes pregnant while taking this drug to reduce the risk of NSAID-induced ulcers, the drug should be discontinued and the patient apprised of the potential hazard to the fetus. Labor and delivery Cytotec can induce or augment uterine contractions. Vaginal administration of Cytotec, outside of its approved indication, has been used as a cervical ripening agent, for the induction of labor and for treatment of serious postpartum hemorrhage in the presence of uterine atony.

Uterine activity and fetal status should be monitored by trained obstetrical personnel in a hospital setting. The risk of uterine rupture associated with misoprostol use in pregnancy increases with advancing gestational ages and prior uterine surgery, including Cesarean delivery.

Postpartum bleeding[ edit ] Misoprostol is also used to prevent and treat post-partum bleeding. Orally administered misoprostol was marginally less effective than oxytocin.

Rectally administered misoprostol was reported in a variety of case reports and randomised controlled trials. One estimate is that it would require around 61, people enrolled in randomized controlled trials to detect a difference in serious fetal complications and about , people to detect a difference in serious maternal complications.

This agent also causes cervical ripening with softening and dilation of the cervix. Misoprostol binds to and stimulates prostaglandin E1 receptors, prostaglandin EP3 receptor and prostaglandin EP4 receptor but not Prostaglandin EP1 receptor and therefore is expected to have a more restricted range of physiological and potentially toxic actions than prostaglandin E2 or other analogs which activate all four prostaglandin receptors. Illegal medically unsupervised misoprostol abortions in Brazil are associated with a lower complication rate than other forms of illegal self-induced abortion, but are still associated with a higher complication rate than legal, medically supervised surgical and medical abortions.

Failed misoprostol abortions are associated with birth defects in some cases.

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