Since the duration of action of hydrocodone may exceed that of the naloxone, the patient should be kept under continuous surveillance and repeated doses of the antagonist should be administered as needed to maintain adequate respiration.
A narcotic antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression. Serum acetaminophen levels should be obtained, since levels four or more hours following ingestion help predict acetaminophen toxicity.
Do not await acetaminophen assay results before initiating treatment. Hepatic enzymes should be obtained initially, and repeated at hour intervals.
The toxic dose for adults for acetaminophen is 10 g. Patients known to be hypersensitive to other opioids may exhibit cross sensitivity to hydrocodone. Most of these involve the central nervous system and smooth muscle. The precise mechanism of action of hydrocodone and other opiates is not known, although it is believed to relate to the existence of opiate receptors in the central nervous system.
In addition to analgesia , narcotics may produce drowsiness, changes in mood and mental clouding. The analgesic action of acetaminophen involves peripheral influences, but the specific mechanism is as yet undetermined. Antipyretic activity is mediated through hypothalamic heat regulating centers. Acetaminophen inhibits prostaglandin synthetase. Therapeutic doses of acetaminophen have negligible effects on the cardiovascular or respiratory systems; however, toxic doses may cause circulatory failure and rapid, shallow breathing.
The behavior of the individual components is described below. This prescription medicine contains not only hydrocodone but also acetaminophen. Acetaminophen treats pain differently from oxycodone, by stopping pain signals, but it can cause liver damage or even liver failure if too much is taken in a certain window of time.
The acetaminophen component is just one more reason Lortab strengths and doses are relevant to people taking this medicine. The dosing guidelines for Lortab strengths are generally based around the acetaminophen even more than the opioid component because you are more likely to experience adverse side effects or overdose on acetaminophen before hydrocodone. Lortab Strengths Lortab comes in several different strengths, starting with 2. This medicine can slow or stop your breathing, and may be habit-forming.
Use only your prescribed dose. Never share acetaminophen and hydrocodone with another person. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. An overdose of acetaminophen can damage your liver or cause death.
However, the dose is usually not more than 6 tablets per day. For oral dosage form 10 mg per mg tablets: Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions Portions of this document last updated: Acetaminophen inhibits prostaglandin synthetase.
Therapeutic doses of acetaminophen have negligible effects on the cardiovascular or respiratory systems; however, toxic doses may cause circulatory failure and rapid, shallow breathing. Pharmacokinetics The behavior of the individual components is described below. Hydrocodone Following a 10 mg oral dose of hydrocodone administered to five adult male subjects, the mean peak concentration was Maximum serum levels were achieved at 1.
Acetaminophen Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1. Elimination of acetaminophen is principally by liver metabolism conjugation and subsequent renal excretion of metabolites. Indications and Usage for Lortab Lortab hydrocodone bitartrate and acetaminophen tablets are indicated for the relief of moderate to moderately severe pain.
Contraindications Lortab tablets should not be administered to patients who have previously exhibited hypersensitivity to hydrocodone or acetaminophen. Patients known to be hypersensitive to other opioids may exhibit cross-sensitivity to hydrocodone. Warnings Hepatotoxicity Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death.
Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed milligrams per day, and often involve more than one acetaminophen containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophen-containing products.
The risk of acute liver failure is higher in individuals with underlying liver disease and in individuals who ingest alcohol while taking acetaminophen. Instruct patients to look for acetaminophen or APAP on package labels and not to use more than one product that contains acetaminophen. Instruct patients to seek medical attention immediately upon ingestion of more than milligrams of acetaminophen per day, even if they feel well. Seek emergency medical attention or call the Poison Help line at An overdose of acetaminophen and hydrocodone can be fatal.
The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.
Overdose symptoms may also include extreme drowsiness, pinpoint pupils, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing What should I avoid while taking Lortab?
This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how Lortab will affect you. Dizziness or severe drowsiness can cause falls or other accidents. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen sometimes abbreviated as APAP is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose.
Check the label to see if a medicine contains acetaminophen or APAP. It may increase your risk of liver damage while taking acetaminophen. Lortab side effects Get emergency medical help if you have signs of an allergic reaction to Lortab:
Therapeutic doses of acetaminophen have negligible effects on the cardiovascular or respiratory lortab however, toxic doses may cause circulatory failure and rapid, shallow breathing. Hydrocodone bitartrate is an opioid analgesic and antitussive and occurs as fine, white crystals or as a crystalline powder. Ask your doctor before making any changes in how or info you take your medications. Most of these involve the central nervous system and smooth muscle. Since the duration of action of hydrocodone may exceed that of the antagonist, the patient should be kept under continued surveillance, and repeated doses of the antagonist should be administered as needed to maintain adequate respiration. Dosage Guide Lortab is a controlled substance, meaning the DEA makes it so that this drug can only be used by prescription. Antipyretic activity is mediated through hypothalamic heat regulating centers. This medication may impair your thinking or reactions. Children 4 to 6 years of age and weighing 16 to 22 kg—3. Other drugs may interact with acetaminophen and hydrocodone, lortab 5 mg info, including prescription and over-the-counter medicines, vitamins, and herbal products. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. Acetaminophen inhibits prostaglandin synthetase. The maximum total daily dosage of 5 mg Lortab is 12 tablets. Adults—15 milliliters mL or 1 tablespoonful every 4 to 6 hours as needed.
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